Losartan Potassium And Hydrochlorothiazide
Generic Name: losartan potassium and hydrochlorothiazide
Brand Names:
Losartan Potassium And Hydrochlorothiazide
Losartan potassium and hydrochlorothiazide is a combination tablet containing an angiotensin II receptor blocker and a diuretic for the treatment of hypertension and reduction of stroke risk in hypertensive patients with left ventricular hypertrophy.
Overview
Losartan potassium and hydrochlorothiazide is a combination tablet containing an angiotensin II receptor blocker and a diuretic for the treatment of hypertension and reduction of stroke risk in hypertensive patients with left ventricular hypertrophy.
Uses
Treatment of hypertension to lower blood pressure and reduce risk of cardiovascular events. Reduction of stroke risk in hypertensive patients with left ventricular hypertrophy.
Dosage
Usual starting dose: 50/12.5 mg once daily. Titrate as needed to maximum of 100/25 mg once daily after 3 weeks.
Side Effects
Most common: dizziness, upper respiratory infection, cough, back pain. Serious reactions include angioedema, hypotension, acute renal failure, electrolyte imbalances.
Interactions
Risk of hyperkalemia with potassium-increasing agents. Lithium toxicity risk. NSAIDs reduce efficacy. Dual RAS blockade increases adverse effects.
Warnings
Black box warning: Fetal toxicity - when pregnancy is detected, discontinue as soon as possible. Risk of hypotension in volume-depleted patients. Monitor renal function and electrolytes. Acute angle-closure glaucoma possible. Contraindicated with hypersensitivity to any component, anuria, or coadministration with aliskiren in diabetic patients.
Pregnancy
Can cause fetal harm in second/third trimesters. Discontinue immediately if pregnancy detected. Thiazides cross placenta. Not recommended during breastfeeding.
Storage
Store at room temperature 20-25 degrees C (68-77 degrees F) in tightly closed container away from light.
Frequently Asked Questions
What is Losartan Potassium And Hydrochlorothiazide used for?▼
Treatment of hypertension to lower blood pressure and reduce risk of cardiovascular events. Reduction of stroke risk in hypertensive patients with left ventricular hypertrophy.
What are the side effects of Losartan Potassium And Hydrochlorothiazide?▼
Most common: dizziness, upper respiratory infection, cough, back pain. Serious reactions include angioedema, hypotension, acute renal failure, electrolyte imbalances.
Can I take Losartan Potassium And Hydrochlorothiazide during pregnancy?▼
Can cause fetal harm in second/third trimesters. Discontinue immediately if pregnancy detected. Thiazides cross placenta. Not recommended during breastfeeding.
What are the important warnings for Losartan Potassium And Hydrochlorothiazide?▼
Black box warning: Fetal toxicity - when pregnancy is detected, discontinue as soon as possible. Risk of hypotension in volume-depleted patients. Monitor renal function and electrolytes. Acute angle-closure glaucoma possible. Contraindicated with hypersensitivity to any component, anuria, or coadministration with aliskiren in diabetic patients.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.