Mepivacaine Hydrochloride
Generic Name: mepivacaine hydrochloride
Brand Names:
Scandonest 3% Plain
DESCRIPTION: Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride with the following structural formula: C 15 H 22 N 2 O • HCI M.W. 282.81 It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis. DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED. SCANDONEST ® 3% Plain (mepivacaine hydrochloride injection 3% (51 mg/1.7 mL) (30 mg/mL)) is a sterile solution for injection.
Overview
DESCRIPTION: Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride with the following structural formula: C 15 H 22 N 2 O • HCI M.W. 282.81 It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis. DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED. SCANDONEST ® 3% Plain (mepivacaine hydrochloride injection 3% (51 mg/1.7 mL) (30 mg/mL)) is a sterile solution for injection.
Uses
INDICATIONS AND USAGE: Mepivacaine is indicated for production of local anesthesia for dental procedures by infiltration or nerve block in adults and pediatric patients.
Dosage
DOSAGE AND ADMINISTRATION: As with all local anesthetics, the dose varies and depends upon the area to be anesthetized, the vascularity of the tissues, individual tolerance and the technique of anesthesia. The lowest dose needed to provide effective anesthesia should be administered. For specific techniques and procedures refer to standard dental manuals and textbooks. For infiltration and block injections in the upper or lower jaw, the average dose of 1 cartridge will usually suffice. Each cartridge contains 1.7 mL (51 mg of mepivacaine). 270 mg of mepivacaine (5.3 cartridges of Scandonest 3%) is usually adequate to effect anesthesia of the entire oral cavity.
Side Effects
ADVERSE REACTIONS: Reactions to SCANDONEST ® are characteristic of those associated with other amide-type local anesthetics. Systemic adverse reactions involving the central nervous system and the cardiovascular system usually result from high plasma levels (which may be due to excessive dosage, rapid absorption, inadvertent intravascular injection, or slow metabolic degradation), injection technique, or volume of injection. A small number of reactions may result from hypersensitivity, idiosyncrasy or diminished tolerance to normal dosage on the part of the patient. Persistent paresthesias of the lips, tongue, and oral tissues have been reported with the use of mepivacaine, with slow, incomplete, or no recovery.
Interactions
Clinically Significant Drug Interactions: Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: EXAMPLES OF DRUGS ASSOCIATED WITH METHEMOGLOBINEMIA: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic Agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoc...
Warnings
WARNINGS: RESUSCITATIVE EQUIPMENT AND DRUGS SHOULD BE IMMEDIATELY AVAILABLE. (See ADVERSE REACTIONS ). Reactions resulting in fatality have occurred on rare occasions with the use of local anesthetics, even in the absence of a history of hypersensitivity. Fatalities may occur with use of local anesthetics in the head and neck region as the result of retrograde arterial flow to vital CNS areas even when maximum recommended doses are observed. The practitioner should be alert to early evidences of alteration in sensorium or vital signs. SCANDONEST ® 3% Plain is SULFITE FREE. Methemoglobinemia: Cases of methemoglobinemia have been reported in association with local anesthetic use; SCANDONEST ® , along with other local anesthetics, is capable of producing this condition. CONTRAINDICATIONS: SCANDONEST ® is contraindicated in patients with a known hypersensitivity to amide-type local anesthetics.
Pregnancy
Pregnancy: Teratogenic Effects: Pregnancy Category C: Animal reproduction studies have not been conducted with this solution. It is also not known whether this solution can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. This solution should be given to a pregnant woman only if clearly needed.
Storage
Solution should be stored at controlled room temperature, below 25°C (77°F). Protect from light. Do not permit to freeze. BOXES: For protection from light, retain in box until time of use. Once opened, the box should be reclosed by closing the top flap. Cartridge warmers should not be used with SCANDONEST ® product.
Frequently Asked Questions
What is Mepivacaine Hydrochloride used for?▼
INDICATIONS AND USAGE: Mepivacaine is indicated for production of local anesthesia for dental procedures by infiltration or nerve block in adults and pediatric patients.
What are the side effects of Mepivacaine Hydrochloride?▼
ADVERSE REACTIONS: Reactions to SCANDONEST ® are characteristic of those associated with other amide-type local anesthetics. Systemic adverse reactions involving the central nervous system and the cardiovascular system usually result from high plasma levels (which may be due to excessive dosage, rapid absorption, inadvertent intravascular injection, or slow metabolic degradation), injection technique, or volume of injection. A small number of reactions may result from hypersensitivity, idiosyncrasy or diminished tolerance to normal dosage on the part of the patient. Persistent paresthesias of the lips, tongue, and oral tissues have been reported with the use of mepivacaine, with slow, incomplete, or no recovery.
Can I take Mepivacaine Hydrochloride during pregnancy?▼
Pregnancy: Teratogenic Effects: Pregnancy Category C: Animal reproduction studies have not been conducted with this solution. It is also not known whether this solution can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. This solution should be given to a pregnant woman only if clearly needed.
What are the important warnings for Mepivacaine Hydrochloride?▼
WARNINGS: RESUSCITATIVE EQUIPMENT AND DRUGS SHOULD BE IMMEDIATELY AVAILABLE. (See ADVERSE REACTIONS ). Reactions resulting in fatality have occurred on rare occasions with the use of local anesthetics, even in the absence of a history of hypersensitivity. Fatalities may occur with use of local anesthetics in the head and neck region as the result of retrograde arterial flow to vital CNS areas even when maximum recommended doses are observed. The practitioner should be alert to early evidences of alteration in sensorium or vital signs. SCANDONEST ® 3% Plain is SULFITE FREE. Methemoglobinemia: Cases of methemoglobinemia have been reported in association with local anesthetic use; SCANDONEST ® , along with other local anesthetics, is capable of producing this condition. CONTRAINDICATIONS: SCANDONEST ® is contraindicated in patients with a known hypersensitivity to amide-type local anesthetics.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.