Metoprolol Succinate Er Tablets
Generic Name: metoprolol succinate er tablets
Brand Names:
Metoprolol Succinate
Metoprolol succinate ER tablets are a beta-1 selective adrenergic blocker in extended-release form indicated for treating hypertension, angina pectoris, and heart failure.
Overview
Metoprolol succinate ER tablets are a beta-1 selective adrenergic blocker in extended-release form indicated for treating hypertension, angina pectoris, and heart failure.
Uses
Indicated for treating hypertension, angina pectoris, and heart failure. For hypertension: lowers blood pressure to reduce risk of cardiovascular events. For angina: reduces attacks and improves exercise tolerance. For heart failure: reduces cardiovascular mortality and hospitalization risk.
Dosage
Administer once daily with titration at weekly or longer intervals as needed. Hypertension: starting 25-100 mg daily. Angina: starting 100 mg daily. Heart failure: starting 12.5-25 mg daily. Pediatric (6+ years): 1 mg/kg once daily maximum 50 mg initially. Maximum studied dose 400 mg daily.
Side Effects
Most common (>2%): tiredness, dizziness, depression, diarrhea, shortness of breath, bradycardia, and rash. Post-operative: increased bradycardia, hypotension, stroke, and death compared to placebo.
Interactions
Catecholamine-depleting drugs have additive effects. CYP2D6 inhibitors (quinidine, fluoxetine, paroxetine, propafenone) increase metoprolol concentrations. Digitalis glycosides, clonidine, diltiazem, verapamil increase bradycardia risk.
Warnings
Abrupt cessation may exacerbate myocardial ischemia. Risk of worsening heart failure during titration. Avoid in bronchospastic disease. Bradycardia risk with concomitant drugs. Pheochromocytoma requires alpha-blocker first. May mask hypoglycemia signs. Can precipitate thyroid storm if abruptly withdrawn. Contraindicated in severe bradycardia, second/third-degree heart block, cardiogenic shock, decompensated heart failure.
Pregnancy
Available data show no drug-associated birth defect risk, but inconsistent reports of growth restriction and preterm birth exist. Neonates exposed in utero may experience hypotension, hypoglycemia, bradycardia, respiratory depression. Metoprolol present in breast milk.
Storage
Store at 25 degrees C (77 degrees F); excursions permitted to 15-30 degrees C (59-86 degrees F).
Frequently Asked Questions
What is Metoprolol Succinate Er Tablets used for?▼
Indicated for treating hypertension, angina pectoris, and heart failure. For hypertension: lowers blood pressure to reduce risk of cardiovascular events. For angina: reduces attacks and improves exercise tolerance. For heart failure: reduces cardiovascular mortality and hospitalization risk.
What are the side effects of Metoprolol Succinate Er Tablets?▼
Most common (>2%): tiredness, dizziness, depression, diarrhea, shortness of breath, bradycardia, and rash. Post-operative: increased bradycardia, hypotension, stroke, and death compared to placebo.
Can I take Metoprolol Succinate Er Tablets during pregnancy?▼
Available data show no drug-associated birth defect risk, but inconsistent reports of growth restriction and preterm birth exist. Neonates exposed in utero may experience hypotension, hypoglycemia, bradycardia, respiratory depression. Metoprolol present in breast milk.
What are the important warnings for Metoprolol Succinate Er Tablets?▼
Abrupt cessation may exacerbate myocardial ischemia. Risk of worsening heart failure during titration. Avoid in bronchospastic disease. Bradycardia risk with concomitant drugs. Pheochromocytoma requires alpha-blocker first. May mask hypoglycemia signs. Can precipitate thyroid storm if abruptly withdrawn. Contraindicated in severe bradycardia, second/third-degree heart block, cardiogenic shock, decompensated heart failure.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.