Naproxen And Esomeprazole Magnesium
Generic Name: naproxen and esomeprazole magnesium
Brand Names:
Naproxen And Esomeprazole Magnesium
Naproxen and esomeprazole magnesium delayed-release tablets combine an NSAID with a proton pump inhibitor for arthritis symptom relief while reducing naproxen-associated gastric ulcer risk.
Overview
Naproxen and esomeprazole magnesium delayed-release tablets combine an NSAID with a proton pump inhibitor for arthritis symptom relief while reducing naproxen-associated gastric ulcer risk.
Uses
Indicated for adults and adolescents 12+ years requiring naproxen for arthritis relief (osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis) with esomeprazole to decrease naproxen-associated gastric ulcer risk.
Dosage
Swallow tablets whole 30+ minutes before meals. Adults/adolescents >50 kg: one tablet twice daily of 375mg/20mg or 500mg/20mg. Adolescents 38-50 kg: one 375mg/20mg tablet twice daily. Avoid in moderate/severe renal or severe hepatic impairment.
Side Effects
Most common (>5%): gastritis and diarrhea. Others include upper respiratory infection, flatulence, headache, constipation, abdominal pain, and dizziness. Serious reactions possible including GI bleeding, cardiovascular events, and liver injury.
Interactions
Major interactions with anticoagulants (increased bleeding), clopidogrel (avoid), aspirin, ACE inhibitors/ARBs, diuretics, lithium, methotrexate, digoxin, and CYP2C19 inducers (St. John's Wort, rifampin - avoid).
Warnings
Black box warning: Risk of serious cardiovascular thrombotic events (MI, stroke) and GI bleeding/ulceration/perforation. Elderly and those with prior peptic ulcer disease or GI bleeding face greatest GI risk. Use lowest naproxen dose for shortest duration. Contraindicated post-CABG surgery and with rilpivirine-containing products.
Pregnancy
Avoid NSAIDs at approximately 30 weeks gestation onward due to premature ductus arteriosus closure risk. Limit use 20-30 weeks to lowest dose/shortest duration due to oligohydramnios/fetal renal dysfunction risk.
Frequently Asked Questions
What is Naproxen And Esomeprazole Magnesium used for?▼
Indicated for adults and adolescents 12+ years requiring naproxen for arthritis relief (osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis) with esomeprazole to decrease naproxen-associated gastric ulcer risk.
What are the side effects of Naproxen And Esomeprazole Magnesium?▼
Most common (>5%): gastritis and diarrhea. Others include upper respiratory infection, flatulence, headache, constipation, abdominal pain, and dizziness. Serious reactions possible including GI bleeding, cardiovascular events, and liver injury.
Can I take Naproxen And Esomeprazole Magnesium during pregnancy?▼
Avoid NSAIDs at approximately 30 weeks gestation onward due to premature ductus arteriosus closure risk. Limit use 20-30 weeks to lowest dose/shortest duration due to oligohydramnios/fetal renal dysfunction risk.
What are the important warnings for Naproxen And Esomeprazole Magnesium?▼
Black box warning: Risk of serious cardiovascular thrombotic events (MI, stroke) and GI bleeding/ulceration/perforation. Elderly and those with prior peptic ulcer disease or GI bleeding face greatest GI risk. Use lowest naproxen dose for shortest duration. Contraindicated post-CABG surgery and with rilpivirine-containing products.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.