Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide
Generic Name: olmesartan medoxomil / amlodipine besylate / hydrochlorothiazide
Brand Names:
Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide
Fixed combination tablet containing olmesartan medoxomil (angiotensin II receptor blocker), amlodipine besylate (calcium channel blocker), and hydrochlorothiazide (thiazide diuretic) for oral administration in the treatment of hypertension.
Overview
Fixed combination tablet containing olmesartan medoxomil (angiotensin II receptor blocker), amlodipine besylate (calcium channel blocker), and hydrochlorothiazide (thiazide diuretic) for oral administration in the treatment of hypertension.
Uses
Indicated for the treatment of hypertension, to lower blood pressure. Not indicated for initial therapy of hypertension.
Dosage
Dosing once daily. May increase after 2 weeks to a maximum of 40/10/25 mg. Dose is individualized based on previous therapy and patient response.
Side Effects
Common adverse reactions (incidence 2% or greater): dizziness, peripheral edema, headache, fatigue, nasopharyngitis, muscle spasms, nausea, upper respiratory tract infection, diarrhea, urinary tract infection, joint swelling.
Interactions
NSAIDs may reduce antihypertensive effect. Dual RAS blockade increases risk of hypotension and hyperkalemia. Interactions with colesevelam, lithium, simvastatin, CYP3A inhibitors, immunosuppressants, and antidiabetic drugs.
Warnings
Fetal toxicity: Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. When pregnancy is detected, discontinue as soon as possible. Additional warnings include hypotension risk, renal impairment, hepatic impairment, electrolyte imbalances, and sprue-like enteropathy.
Pregnancy
Can cause fetal harm when administered to a pregnant woman. Discontinue immediately upon detection of pregnancy.
Frequently Asked Questions
What is Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide used for?▼
Indicated for the treatment of hypertension, to lower blood pressure. Not indicated for initial therapy of hypertension.
What are the side effects of Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide?▼
Common adverse reactions (incidence 2% or greater): dizziness, peripheral edema, headache, fatigue, nasopharyngitis, muscle spasms, nausea, upper respiratory tract infection, diarrhea, urinary tract infection, joint swelling.
Can I take Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide during pregnancy?▼
Can cause fetal harm when administered to a pregnant woman. Discontinue immediately upon detection of pregnancy.
What are the important warnings for Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide?▼
Fetal toxicity: Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. When pregnancy is detected, discontinue as soon as possible. Additional warnings include hypotension risk, renal impairment, hepatic impairment, electrolyte imbalances, and sprue-like enteropathy.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.