Pramipexole Dihydrochloride
Generic Name: pramipexole dihydrochloride
Brand Names:
Pramipexole Dihydrochloride
Pramipexole dihydrochloride is a non-ergot dopamine agonist indicated for the treatment of Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome (RLS).
Overview
Pramipexole dihydrochloride is a non-ergot dopamine agonist indicated for the treatment of Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome (RLS).
Uses
Treatment of Parkinson's disease (PD) and moderate-to-severe primary Restless Legs Syndrome (RLS).
Dosage
For Parkinson's disease, initial treatment starts at 0.375 mg/day, titrated over 7 weeks. For RLS, dosing begins at 0.125 mg taken 2-3 hours before bedtime. Dosage adjustments needed for renal impairment.
Side Effects
Common reactions include nausea, dizziness, somnolence, insomnia, constipation, and hallucinations for Parkinson's disease. Nausea and somnolence reported for RLS.
Interactions
Dopamine antagonists may diminish effectiveness of pramipexole.
Warnings
Risk of falling asleep during activities of daily living. Orthostatic hypotension risk. Impulse control disorders including compulsive gambling, spending, and eating. Hallucinations and psychotic-like behavior. Dyskinesia. Withdrawal symptoms upon rapid dose reduction.
Pregnancy
Insufficient human data. Animal studies showed embryolethality in rats. Lactation inhibition expected.
Frequently Asked Questions
What is Pramipexole Dihydrochloride used for?▼
Treatment of Parkinson's disease (PD) and moderate-to-severe primary Restless Legs Syndrome (RLS).
What are the side effects of Pramipexole Dihydrochloride?▼
Common reactions include nausea, dizziness, somnolence, insomnia, constipation, and hallucinations for Parkinson's disease. Nausea and somnolence reported for RLS.
Can I take Pramipexole Dihydrochloride during pregnancy?▼
Insufficient human data. Animal studies showed embryolethality in rats. Lactation inhibition expected.
What are the important warnings for Pramipexole Dihydrochloride?▼
Risk of falling asleep during activities of daily living. Orthostatic hypotension risk. Impulse control disorders including compulsive gambling, spending, and eating. Hallucinations and psychotic-like behavior. Dyskinesia. Withdrawal symptoms upon rapid dose reduction.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.