Pyridostigmine Bromide Oral
Generic Name: pyridostigmine bromide oral
Brand Names:
Pyridostigmine
DESCRIPTION Pyridostigmine Bromide Oral Solution, USP is an orally active cholinesterase inhibitor. Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. Its structural formula is: Pyridostigmine Bromide Oral Solution, USP contains 60 mg pyridostigmine bromide per teaspoonful in a vehicle containing 5% alcohol, glycerin, lactic acid, sodium benzoate, sorbitol solution, sucrose, FD&C Red No. 40, FD&C Blue No. 1, raspberry flavor and water.
Overview
DESCRIPTION Pyridostigmine Bromide Oral Solution, USP is an orally active cholinesterase inhibitor. Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. Its structural formula is: Pyridostigmine Bromide Oral Solution, USP contains 60 mg pyridostigmine bromide per teaspoonful in a vehicle containing 5% alcohol, glycerin, lactic acid, sodium benzoate, sorbitol solution, sucrose, FD&C Red No. 40, FD&C Blue No. 1, raspberry flavor and water.
Uses
INDICATIONS & USAGE Pyridostigmine Bromide Oral Solution, USP is useful in the treatment of myasthenia gravis.
Dosage
DOSAGE & ADMINISTRATION Pyridostigmine Bromide Oral Solution is available in the following form: Solution: raspberry-flavored, containing 60 mg pyridostigmine bromide per teaspoonful (5 mL). This form permits accurate dosage adjustment for children and "brittle" myasthenic patients who require fractions of 60 mg doses. It is more easily swallowed, especially in the morning, by patients with bulbar involvement. Dosage: The size and frequency of the dosage must be adjusted to the needs of the individual patient. Solution: The average dose is ten 5 mL teaspoonfuls daily, spaced to provide maximum relief when maximum strength is needed. In severe cases as many as 25 teaspoonfuls a day may be required, while in mild cases one to six teaspoonfuls a day may suffice.
Side Effects
ADVERSE REACTIONS The side effects of Pyridostigmine Bromide Oral Solution are most commonly related to over dosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness. Muscarinic side effects can usually be counteracted by atropine, but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the bromide radical, a skin rash may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication.
Warnings
WARNINGS Although failure of patients to show clinical improvement may reflect underdosage, it can also be indicative of overdosage. As is true of all cholinergic drugs, overdosage of Pyridostigmine Bromide Oral Solution may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death. Myasthenic crisis due to an increase in the severity of the disease is also accompanied by extreme muscle weakness, and thus may be difficult to distinguish from cholinergic crisis on a symptomatic basis. CONTRAINDICATIONS Pyridostigmine Bromide Oral Solution is contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below.
Storage
HOW SUPPLIED Pyridostigmine Bromide Oral Solution USP, 60 mg pyridostigmine bromide per teaspoonful (5 mL) and 5% alcohol - bottles of 16 fluid ounces (16 fl. oz.) (NDC 70954-148-10). Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°-30°C (59°-86°F). [See USP Controlled Room Temperature]
Frequently Asked Questions
What is Pyridostigmine Bromide Oral used for?▼
INDICATIONS & USAGE Pyridostigmine Bromide Oral Solution, USP is useful in the treatment of myasthenia gravis.
What are the side effects of Pyridostigmine Bromide Oral?▼
ADVERSE REACTIONS The side effects of Pyridostigmine Bromide Oral Solution are most commonly related to over dosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness. Muscarinic side effects can usually be counteracted by atropine, but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the bromide radical, a skin rash may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication.
What are the important warnings for Pyridostigmine Bromide Oral?▼
WARNINGS Although failure of patients to show clinical improvement may reflect underdosage, it can also be indicative of overdosage. As is true of all cholinergic drugs, overdosage of Pyridostigmine Bromide Oral Solution may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death. Myasthenic crisis due to an increase in the severity of the disease is also accompanied by extreme muscle weakness, and thus may be difficult to distinguish from cholinergic crisis on a symptomatic basis. CONTRAINDICATIONS Pyridostigmine Bromide Oral Solution is contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below.
Related Medications
Echinacea (angustifolia), Lomatium Dissectum, Myrrha, Nasturtium Aquaticum, Propolis, Tabebuia Impetiginosa, Hydrastis Canadensis, Thymus Serpyllum, Glandula Suprarenalis Suis, Lymph Node (suis), Spleen (suis), Thyroidinum (suis), Belladonna, Hypericum Perforatum, Phosphorus, Pyrogenium, Anthracinum, Arsenicum, Carbolicum Acidum, Hepar Sulphuris Calcareum, Lachesis, Variolinum, Botulinum, Dysentery Bacillus, Gaertner Bacillus, Francisella Tularensis, Coxiella Burnetii, Lac Caninum, Malaria Officinalis,
echinacea (angustifolia), lomatium dissectum, myrrha, nasturtium aquaticum, propolis, tabebuia impetiginosa, hydrastis canadensis, thymus serpyllum, glandula suprarenalis suis, lymph node (suis), spleen (suis), thyroidinum (suis), belladonna, hypericum perforatum, phosphorus, pyrogenium, anthracinum, arsenicum, carbolicum acidum, hepar sulphuris calcareum, lachesis, variolinum, botulinum, dysentery bacillus, gaertner bacillus, francisella tularensis, coxiella burnetii, lac caninum, malaria officinalis,
PURPOSE: Anthracinum - inflammation,** Arsenicum Album - weakness,** Belladonna - fever,** Botulinum - migraine,** Carbolicum Acidum - neuralgia,** Coxiella Burnetii – muscle aches,** Dysentery Bacillus - fever,** Echinacea (Angustifolia) - fever,** Francisella Tularensis – burning pain,** Gaertner Bacillus (Bach) - swelling,** Glandula Suprarenalis Suis - burning,** Hepar Sulphuris Calcareum - antiseptic,** Hydrastis Canadensis – nerve pain,** Hypericum Perforatum – shooting pain,** Lac Caninum
Thyroid, Full Strength
thyroid, full strength
Dosage form: POWDER. Active ingredients: SUS SCROFA THYROID (1 kg/kg). Category: BULK INGREDIENT.
Oak
oak
INDICATIONS: For temporary relief of strength and courage with a need to fight against great odds, and never knowing when to let go of the fight.
Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.