Rizatriptan Benzoate
Generic Name: rizatriptan benzoate
Brand Names:
Rizatriptan Benzoate
Rizatriptan benzoate is a selective 5-HT1B/1D receptor agonist available in orally disintegrating tablet form for the acute treatment of migraine.
Overview
Rizatriptan benzoate is a selective 5-HT1B/1D receptor agonist available in orally disintegrating tablet form for the acute treatment of migraine.
Uses
Indicated for the acute treatment of migraine with or without aura in adults and in pediatric patients 6 to 17 years old. Not intended for prevention or for hemiplegic or basilar migraine types.
Dosage
Adults: 5-10 mg single dose with minimum 2-hour intervals between doses, maximum 30 mg per 24 hours. Pediatric (6-17 years): weight-based dosing of 5 mg (under 40 kg) or 10 mg (40 kg and above). Dosage reduction required with propranolol co-administration.
Side Effects
Most common in adults: asthenia/fatigue, somnolence, pain/pressure sensations, and dizziness. Serious reactions include myocardial infarction, arrhythmias, and cerebrovascular events.
Interactions
Propranolol increases rizatriptan plasma levels by 70%. Ergot-containing drugs and other triptans contraindicated within 24 hours. SSRIs/SNRIs carry serotonin syndrome risk.
Warnings
Risk of myocardial ischemia, arrhythmias, cerebrovascular events, and vasospasm reactions. Medication overuse headache and serotonin syndrome risks. Contraindicated in ischemic coronary artery disease, history of stroke or TIA, uncontrolled hypertension, and concurrent MAO inhibitor use.
Pregnancy
Animal studies showed developmental toxicity at high exposures. Human data insufficient to draw definitive conclusions about birth defect risk.
Storage
Store at 20 to 25 degrees C (68 to 77 degrees F).
Frequently Asked Questions
What is Rizatriptan Benzoate used for?▼
Indicated for the acute treatment of migraine with or without aura in adults and in pediatric patients 6 to 17 years old. Not intended for prevention or for hemiplegic or basilar migraine types.
What are the side effects of Rizatriptan Benzoate?▼
Most common in adults: asthenia/fatigue, somnolence, pain/pressure sensations, and dizziness. Serious reactions include myocardial infarction, arrhythmias, and cerebrovascular events.
Can I take Rizatriptan Benzoate during pregnancy?▼
Animal studies showed developmental toxicity at high exposures. Human data insufficient to draw definitive conclusions about birth defect risk.
What are the important warnings for Rizatriptan Benzoate?▼
Risk of myocardial ischemia, arrhythmias, cerebrovascular events, and vasospasm reactions. Medication overuse headache and serotonin syndrome risks. Contraindicated in ischemic coronary artery disease, history of stroke or TIA, uncontrolled hypertension, and concurrent MAO inhibitor use.
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*Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.
Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.