Sacubitril And Valsartan

Generic Name: sacubitril and valsartan

Angiotensin 2 Receptor Blocker [EPC]Over-the-Counter (OTC)

Brand Names:

Sacubitril and valsartan is a combination medication containing a neprilysin inhibitor (sacubitril) and an angiotensin II receptor blocker (valsartan) for the treatment of heart failure.

Overview

Sacubitril and valsartan is a combination medication containing a neprilysin inhibitor (sacubitril) and an angiotensin II receptor blocker (valsartan) for the treatment of heart failure.

Uses

Indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure and reduced ejection fraction. Also indicated for pediatric heart failure in patients aged one year and older.

Dosage

Adult starting dose is 49 mg/51 mg orally twice daily with target maintenance of 97 mg/103 mg orally twice daily. Pediatric dosing is weight-based, ranging from 1.6 to 3.1 mg/kg twice daily.

Side Effects

Common adverse reactions include hypotension (18%), hyperkalemia (12%), cough (9%), dizziness (6%), and renal failure (5%).

Interactions

Avoid concomitant use with ACE inhibitors (36-hour washout required), aliskiren in renal impairment, potassium-sparing diuretics, NSAIDs, and lithium.

Warnings

Fetal toxicity: when pregnancy is detected, discontinue as soon as possible. Risk of angioedema, hypotension, impaired renal function, and hyperkalemia. Contraindicated with ACE inhibitors, history of angioedema, and aliskiren in diabetic patients.

Pregnancy

Drug causes fetal harm when administered during pregnancy. When pregnancy is detected, consider alternative drug treatment.

Storage

Store at 25 degrees C (77 degrees F), excursions permitted between 15 to 30 degrees C. Protect from moisture.

Frequently Asked Questions

What is Sacubitril And Valsartan used for?▼

What are the side effects of Sacubitril And Valsartan?▼

Common adverse reactions include hypotension (18%), hyperkalemia (12%), cough (9%), dizziness (6%), and renal failure (5%).

Can I take Sacubitril And Valsartan during pregnancy?▼

Drug causes fetal harm when administered during pregnancy. When pregnancy is detected, consider alternative drug treatment.

What are the important warnings for Sacubitril And Valsartan?▼

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Medical Disclaimer

This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.