Sodium Phenylacetate And Sodium Benzoate
Generic Name: sodium phenylacetate and sodium benzoate
Brand Names:
Sodium Phenylacetate And Sodium Benzoate
Sodium phenylacetate and sodium benzoate injection is a sterile concentrated solution for intravenous use in the treatment of acute hyperammonemia in patients with urea cycle enzyme deficiencies.
Overview
Sodium phenylacetate and sodium benzoate injection is a sterile concentrated solution for intravenous use in the treatment of acute hyperammonemia in patients with urea cycle enzyme deficiencies.
Uses
Treatment of acute hyperammonemia and associated encephalopathy in pediatric and adult patients with urea cycle enzyme deficiencies, used as adjunctive therapy alongside other interventions.
Dosage
Must be diluted with 10% dextrose before IV administration via central venous catheter only. Loading dose given over 90-120 minutes, followed by equivalent maintenance dose over 24 hours. Dosing based on weight for younger patients and body surface area for larger patients.
Side Effects
Most frequent reactions (6% or greater) include vomiting, hyperglycemia, hypokalemia, convulsions, and mental impairment. Severe reactions range from coagulopathy to respiratory failure.
Interactions
Penicillin, probenecid, valproic acid, and corticosteroids may affect drug disposition or efficacy.
Warnings
Requires central line administration. Risk of extravasation causing tissue necrosis. Careful potassium monitoring required. Risk of fluid overload, phenylacetate neurotoxicity, and metabolic acidosis.
Pregnancy
Insufficient human data. Animal studies not conducted.
Storage
Store at 20-25 degrees C (68-77 degrees F). Excursions permitted 15-30 degrees C.
Frequently Asked Questions
What is Sodium Phenylacetate And Sodium Benzoate used for?▼
Treatment of acute hyperammonemia and associated encephalopathy in pediatric and adult patients with urea cycle enzyme deficiencies, used as adjunctive therapy alongside other interventions.
What are the side effects of Sodium Phenylacetate And Sodium Benzoate?▼
Most frequent reactions (6% or greater) include vomiting, hyperglycemia, hypokalemia, convulsions, and mental impairment. Severe reactions range from coagulopathy to respiratory failure.
Can I take Sodium Phenylacetate And Sodium Benzoate during pregnancy?▼
Insufficient human data. Animal studies not conducted.
What are the important warnings for Sodium Phenylacetate And Sodium Benzoate?▼
Requires central line administration. Risk of extravasation causing tissue necrosis. Careful potassium monitoring required. Risk of fluid overload, phenylacetate neurotoxicity, and metabolic acidosis.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.