Sulfamethoxazole And Trimethoprim
Generic Name: sulfamethoxazole and trimethoprim
Brand Names:
Sulfamethoxazole And Trimethoprim
Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination available in tablets for the treatment of various bacterial infections.
Overview
Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination available in tablets for the treatment of various bacterial infections.
Uses
Treatment of urinary tract infections, acute otitis media in pediatric patients, acute exacerbations of chronic bronchitis, shigellosis, Pneumocystis jirovecii pneumonia, and traveler's diarrhea caused by susceptible bacteria.
Dosage
Adults typically receive one DS tablet (800/160 mg) or two regular tablets (400/80 mg) every 12 hours. Children receive 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim daily in divided doses. Dosage adjustments required for impaired renal function.
Side Effects
Most common are gastrointestinal disturbances and allergic skin reactions. Serious reactions include Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, aplastic anemia, and hepatic necrosis.
Interactions
Avoid concurrent use with dofetilide, methotrexate, cyclosporine, and certain diuretics. Monitor when using with warfarin, phenytoin, digoxin, and oral hypoglycemics.
Warnings
Embryofetal toxicity risk during pregnancy. Hypersensitivity reactions including severe cutaneous adverse reactions. Risk of Clostridioides difficile-associated diarrhea. Contraindicated in infants under 2 months, severe hepatic or renal damage, and megaloblastic anemia from folate deficiency.
Frequently Asked Questions
What is Sulfamethoxazole And Trimethoprim used for?▼
Treatment of urinary tract infections, acute otitis media in pediatric patients, acute exacerbations of chronic bronchitis, shigellosis, Pneumocystis jirovecii pneumonia, and traveler's diarrhea caused by susceptible bacteria.
What are the side effects of Sulfamethoxazole And Trimethoprim?▼
Most common are gastrointestinal disturbances and allergic skin reactions. Serious reactions include Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, aplastic anemia, and hepatic necrosis.
What are the important warnings for Sulfamethoxazole And Trimethoprim?▼
Embryofetal toxicity risk during pregnancy. Hypersensitivity reactions including severe cutaneous adverse reactions. Risk of Clostridioides difficile-associated diarrhea. Contraindicated in infants under 2 months, severe hepatic or renal damage, and megaloblastic anemia from folate deficiency.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.