Trospium Chloride
Generic Name: trospium chloride
Brand Names:
Trospium Chloride
Trospium chloride is a quaternary ammonium muscarinic antagonist for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Overview
Trospium chloride is a quaternary ammonium muscarinic antagonist for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Uses
Indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Dosage
Recommended dosing is 20 mg twice daily taken with water on an empty stomach, at least one hour before meals. Dosage adjustments apply for severe renal impairment (20 mg once daily) and geriatric patients 75 years and older.
Side Effects
Most common adverse reactions: dry mouth (20.1%), constipation (9.6%), and headache (4.2%). Serious reactions include angioedema and Stevens-Johnson syndrome reported post-marketing.
Interactions
Metformin reduces trospium exposure 29-34%. Competition possible with drugs eliminated via active tubular secretion. Digoxin interaction studies showed no effect.
Warnings
Caution for urinary retention risk, angioedema potential, gastrointestinal motility effects, narrow-angle glaucoma, and CNS effects including somnolence. Contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, or known hypersensitivity.
Pregnancy
Should be used during pregnancy only if potential benefit outweighs risk. Animal studies showed no increased developmental risk at recommended human doses.
Storage
Store at 20 to 25 degrees C (68 to 77 degrees F). Excursions permitted to 15 to 30 degrees C.
Frequently Asked Questions
What is Trospium Chloride used for?▼
Indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
What are the side effects of Trospium Chloride?▼
Most common adverse reactions: dry mouth (20.1%), constipation (9.6%), and headache (4.2%). Serious reactions include angioedema and Stevens-Johnson syndrome reported post-marketing.
Can I take Trospium Chloride during pregnancy?▼
Should be used during pregnancy only if potential benefit outweighs risk. Animal studies showed no increased developmental risk at recommended human doses.
What are the important warnings for Trospium Chloride?▼
Caution for urinary retention risk, angioedema potential, gastrointestinal motility effects, narrow-angle glaucoma, and CNS effects including somnolence. Contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, or known hypersensitivity.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.