Resveratrol
Also known as: Trans-Resveratrol, Polyphenol, Red Wine Extract, Grape Seed Extract
Resveratrol is a polyphenolic compound produced by plants in response to stress, particularly found in red grapes, red wine, and berries. It is a potent antioxidant that may activate sirtuins, enzymes involved in cellular aging and longevity pathways. Resveratrol crosses the blood-brain barrier and has been studied for effects on age-related diseases.
Benefits
Powerful antioxidant protecting against cellular damage and oxidative stress; may activate sirtuins and support cellular aging pathways; promotes cardiovascular health and may lower blood pressure; supports brain health and cognitive function; has anti-inflammatory properties; may promote longevity and healthy aging; supports joint health.
Recommended Dosage
Clinical supplementation typically ranges from 150-500 mg daily, with some studies using doses up to 1000 mg. Trans-resveratrol is the active form and has better bioavailability than cis-resveratrol. Taking with meals increases absorption significantly; fat in meals enhances bioavailability. Effects may take weeks to months.
Food Sources
Resveratrol is abundantly found in red grapes, red wine (10-100 mg per glass depending on varietal), berries (blueberries, cranberries), peanuts, and raw cacao. However, processing and cooking reduce resveratrol content; achieving therapeutic supplement doses through food alone is difficult.
Side Effects
Generally well-tolerated at supplemental doses. Mild side effects include nausea, diarrhea, or abdominal discomfort. Headaches and dizziness have been rarely reported. Some individuals may experience allergic reactions if sensitive to grape products. Side effects are typically mild and transient.
Interactions
May increase bleeding risk when combined with anticoagulants or antiplatelet medications; monitor for signs of bleeding. May enhance blood sugar-lowering effects of diabetes medications; monitor glucose if combining. Caution advised with blood pressure medications as resveratrol may lower BP further.
Warnings
Not recommended during pregnancy without medical guidance. Individuals with hormone-sensitive conditions should consult healthcare providers, as some research suggests hormonal effects. Those with bleeding disorders should use cautiously. May increase bleeding during surgical procedures; discontinue 2 weeks before surgery.
Deficiency Symptoms
Resveratrol deficiency is not a clinical condition since it is not an essential nutrient. However, dietary insufficiency of resveratrol-containing foods contributes to increased oxidative stress and accelerated aging processes.
Frequently Asked Questions
What are the benefits of Resveratrol?▼
Powerful antioxidant protecting against cellular damage and oxidative stress; may activate sirtuins and support cellular aging pathways; promotes cardiovascular health and may lower blood pressure; supports brain health and cognitive function; has anti-inflammatory properties; may promote longevity and healthy aging; supports joint health.
What is the recommended dosage for Resveratrol?▼
Clinical supplementation typically ranges from 150-500 mg daily, with some studies using doses up to 1000 mg. Trans-resveratrol is the active form and has better bioavailability than cis-resveratrol. Taking with meals increases absorption significantly; fat in meals enhances bioavailability. Effects may take weeks to months.
What foods contain Resveratrol?▼
Resveratrol is abundantly found in red grapes, red wine (10-100 mg per glass depending on varietal), berries (blueberries, cranberries), peanuts, and raw cacao. However, processing and cooking reduce resveratrol content; achieving therapeutic supplement doses through food alone is difficult.
What are the side effects of Resveratrol?▼
Generally well-tolerated at supplemental doses. Mild side effects include nausea, diarrhea, or abdominal discomfort. Headaches and dizziness have been rarely reported. Some individuals may experience allergic reactions if sensitive to grape products. Side effects are typically mild and transient.
What are the symptoms of Resveratrol deficiency?▼
Resveratrol deficiency is not a clinical condition since it is not an essential nutrient. However, dietary insufficiency of resveratrol-containing foods contributes to increased oxidative stress and accelerated aging processes.
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Supplement Disclaimer
This supplement information is for educational purposes only and should not replace professional medical advice. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare provider before starting any supplement, especially if you are pregnant, nursing, taking medications, or have a medical condition.