Dutasteride
Generic Name: dutasteride
Brand Names:
Dutasteride
Dutasteride is a synthetic 4-azasteroid compound that is a selective inhibitor of both type 1 and type 2 isoforms of steroid 5 alpha-reductase, used for treating benign prostatic hyperplasia.
Overview
Dutasteride is a synthetic 4-azasteroid compound that is a selective inhibitor of both type 1 and type 2 isoforms of steroid 5 alpha-reductase, used for treating benign prostatic hyperplasia.
Uses
Indicated for treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to improve symptoms, reduce risk of acute urinary retention, and reduce risk of need for BPH-related surgery.
Dosage
0.5 mg once daily as monotherapy; 0.5 mg once daily combined with tamsulosin 0.4 mg once daily. Capsules should be swallowed whole.
Side Effects
Most common: impotence, decreased libido, ejaculation disorders, and breast disorders.
Interactions
Use caution with potent CYP3A4 inhibitors (e.g., ritonavir). No significant interactions with tamsulosin, digoxin, or warfarin.
Warnings
Dutasteride reduces PSA by approximately 50%. May increase risk of high-grade prostate cancer. Women who are pregnant should not handle capsules. Contraindicated in pregnancy and clinically significant hypersensitivity to dutasteride or other 5 alpha-reductase inhibitors.
Pregnancy
Contraindicated in pregnancy. May cause harm to male fetus external genitalia development.
Frequently Asked Questions
What is Dutasteride used for?▼
Indicated for treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to improve symptoms, reduce risk of acute urinary retention, and reduce risk of need for BPH-related surgery.
What are the side effects of Dutasteride?▼
Most common: impotence, decreased libido, ejaculation disorders, and breast disorders.
Can I take Dutasteride during pregnancy?▼
Contraindicated in pregnancy. May cause harm to male fetus external genitalia development.
What are the important warnings for Dutasteride?▼
Dutasteride reduces PSA by approximately 50%. May increase risk of high-grade prostate cancer. Women who are pregnant should not handle capsules. Contraindicated in pregnancy and clinically significant hypersensitivity to dutasteride or other 5 alpha-reductase inhibitors.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.