Empagliflozin
Generic Name: empagliflozin
Brand Names:
Jardiance
Empagliflozin is an SGLT2 inhibitor available as film-coated tablets for cardiovascular risk reduction, kidney disease prevention, and glycemic control in type 2 diabetes.
Overview
Empagliflozin is an SGLT2 inhibitor available as film-coated tablets for cardiovascular risk reduction, kidney disease prevention, and glycemic control in type 2 diabetes.
Uses
Approved to reduce cardiovascular death risk and heart failure hospitalization, decrease eGFR decline and kidney disease progression, lower cardiovascular mortality in type 2 diabetes with existing heart disease, and improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes.
Dosage
10 mg orally once daily in the morning, taken with or without food, with potential increase to 25 mg for additional glycemic control.
Side Effects
Most common include urinary tract infections and female genital mycotic infections. Serious risks include diabetic ketoacidosis, volume depletion, and necrotizing fasciitis.
Interactions
Notable interactions with diuretics, insulin, insulin secretagogues, and lithium. Affects urine glucose testing reliability.
Warnings
Major concerns include ketoacidosis risk, volume depletion, genitourinary infections, hypoglycemia, lower limb amputation, and hypersensitivity reactions. Contraindicated in hypersensitivity to empagliflozin or excipients.
Pregnancy
Not recommended during the second and third trimesters of pregnancy based on animal data showing renal effects.
Frequently Asked Questions
What is Empagliflozin used for?▼
Approved to reduce cardiovascular death risk and heart failure hospitalization, decrease eGFR decline and kidney disease progression, lower cardiovascular mortality in type 2 diabetes with existing heart disease, and improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes.
What are the side effects of Empagliflozin?▼
Most common include urinary tract infections and female genital mycotic infections. Serious risks include diabetic ketoacidosis, volume depletion, and necrotizing fasciitis.
Can I take Empagliflozin during pregnancy?▼
Not recommended during the second and third trimesters of pregnancy based on animal data showing renal effects.
What are the important warnings for Empagliflozin?▼
Major concerns include ketoacidosis risk, volume depletion, genitourinary infections, hypoglycemia, lower limb amputation, and hypersensitivity reactions. Contraindicated in hypersensitivity to empagliflozin or excipients.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.