Ertapenem
Generic Name: ertapenem
Brand Names:
Ertapenem Sodium
Ertapenem is a sterile, synthetic, parenteral carbapenem antibiotic structurally related to beta-lactam antibiotics for the treatment of moderate to severe bacterial infections.
Overview
Ertapenem is a sterile, synthetic, parenteral carbapenem antibiotic structurally related to beta-lactam antibiotics for the treatment of moderate to severe bacterial infections.
Uses
Treatment of moderate to severe infections including complicated intra-abdominal infections, skin/skin structure infections, community-acquired pneumonia, urinary tract infections, acute pelvic infections, and surgical site infection prophylaxis.
Dosage
Adults/pediatric 13+ years: 1 g once daily IV/IM. Pediatric 3 months-12 years: 15 mg/kg twice daily (not to exceed 1 g/day). IV infusion over 30 minutes for up to 14 days.
Side Effects
Most common (5% or more): diarrhea, nausea, headache, infused vein complication in adults. Diarrhea, vomiting, infusion site pain in pediatrics.
Interactions
Probenecid inhibits renal excretion. Valproic acid/divalproex sodium reduces valproic acid concentrations.
Warnings
Hypersensitivity reactions, seizure potential, valproic acid interactions, C. difficile-associated diarrhea. Contraindicated in known hypersensitivity to product components or anaphylactic reactions to beta-lactams.
Pregnancy
Animal studies showed no developmental malformations at therapeutic exposures. Limited human data available.
Frequently Asked Questions
What is Ertapenem used for?▼
Treatment of moderate to severe infections including complicated intra-abdominal infections, skin/skin structure infections, community-acquired pneumonia, urinary tract infections, acute pelvic infections, and surgical site infection prophylaxis.
What are the side effects of Ertapenem?▼
Most common (5% or more): diarrhea, nausea, headache, infused vein complication in adults. Diarrhea, vomiting, infusion site pain in pediatrics.
Can I take Ertapenem during pregnancy?▼
Animal studies showed no developmental malformations at therapeutic exposures. Limited human data available.
What are the important warnings for Ertapenem?▼
Hypersensitivity reactions, seizure potential, valproic acid interactions, C. difficile-associated diarrhea. Contraindicated in known hypersensitivity to product components or anaphylactic reactions to beta-lactams.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.