Ethacrynic Acid
Generic Name: ethacrynic acid
Brand Names:
Ethacrynic Acid
Ethacrynic acid is an unsaturated ketone derivative of aryloxyacetic acid, a potent loop diuretic available as white crystalline powder tablets.
Overview
Ethacrynic acid is an unsaturated ketone derivative of aryloxyacetic acid, a potent loop diuretic available as white crystalline powder tablets.
Uses
Treatment of edema in congestive heart failure, cirrhosis, renal disease, nephrotic syndrome, ascites, and hospitalized pediatric patients with congenital heart disease.
Dosage
Adults: 50-100 mg initial dose; maintenance 50-200 mg daily in 25-50 mg increments. Pediatric: 25 mg initial with 25 mg stepwise increases.
Side Effects
Gastrointestinal effects, hyperuricemia, acute gout, deafness, tinnitus, vertigo, skin rash, headache, and thrombocytopenia reported.
Interactions
Avoid with lithium, aminoglycosides, cephalosporins; warfarin dosage may need reduction; NSAIDs may reduce diuretic effects.
Warnings
Risk of profound electrolyte and water loss; monitor weight and electrolytes; avoid rapid weight loss in elderly cardiac patients; deafness possible. Contraindicated in anuria, severe watery diarrhea history, and infants.
Pregnancy
Pregnancy Category B. No adequate and well-controlled studies in pregnant women but animal studies showed no fetal abnormalities.
Storage
Store in tightly closed container at 25C (77F); excursions permitted 15-30C (59-86F).
Frequently Asked Questions
What is Ethacrynic Acid used for?▼
Treatment of edema in congestive heart failure, cirrhosis, renal disease, nephrotic syndrome, ascites, and hospitalized pediatric patients with congenital heart disease.
What are the side effects of Ethacrynic Acid?▼
Gastrointestinal effects, hyperuricemia, acute gout, deafness, tinnitus, vertigo, skin rash, headache, and thrombocytopenia reported.
Can I take Ethacrynic Acid during pregnancy?▼
Pregnancy Category B. No adequate and well-controlled studies in pregnant women but animal studies showed no fetal abnormalities.
What are the important warnings for Ethacrynic Acid?▼
Risk of profound electrolyte and water loss; monitor weight and electrolytes; avoid rapid weight loss in elderly cardiac patients; deafness possible. Contraindicated in anuria, severe watery diarrhea history, and infants.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.