Lidocaine Hydrochloride And Epinephrine Bitartrate
Generic Name: lidocaine hydrochloride and epinephrine bitartrate
Brand Names:
Lidocaine
Lidocaine hydrochloride and epinephrine bitartrate is a sterile isotonic solution containing a local anesthetic and vasoconstrictor for parenteral injection in single-dose cartridges, indicated for the production of local anesthesia for dental procedures.
Overview
Lidocaine hydrochloride and epinephrine bitartrate is a sterile isotonic solution containing a local anesthetic and vasoconstrictor for parenteral injection in single-dose cartridges, indicated for the production of local anesthesia for dental procedures.
Uses
Indicated for the production of local anesthesia for dental procedures by nerve block or infiltration techniques.
Dosage
Dosage varies by patient status, oral area, and technique. For routine procedures, 1:100,000 epinephrine preferred. Infiltration/mandibular block: 1.0-5.0 mL usually effective. Children under 10: rarely exceeds 0.9-1.0 mL per procedure. Maximum: 7 mg/kg body weight, not exceeding 500 mg for adults.
Side Effects
CNS effects include lightheadedness, nervousness, confusion, drowsiness, tremors, convulsions, respiratory depression. Cardiovascular: bradycardia, hypotension, cardiac collapse. Allergic reactions characterized by cutaneous lesions, urticaria, edema, anaphylactoid reactions, or dyspnea.
Interactions
Epinephrine with MAOIs, tricyclic antidepressants, or phenothiazines may cause severe hypotension/hypertension. Beta-blockers may cause hypertension and bradycardia. Concurrent methemoglobinemia-inducing drugs increase risk.
Warnings
Practitioners must be versed in emergency management. Aspiration required before injection. Contains potassium metabisulfite (sulfite). Risk of methemoglobinemia in susceptible populations. Vasoconstrictor use requires careful monitoring in cardiac patients. Contraindicated in patients with known history of hypersensitivity to local anesthetics of the amide type.
Pregnancy
Reproduction studies in rats at 6.6 times human dose revealed no evidence of harm to fetus. No adequate well-controlled studies in pregnant women. Use with caution in pregnancy; unknown if excreted in breast milk.
Storage
Store below 25 degrees C (77 degrees F), protected from light. Do not freeze. Do not autoclave.
Frequently Asked Questions
What is Lidocaine Hydrochloride And Epinephrine Bitartrate used for?▼
Indicated for the production of local anesthesia for dental procedures by nerve block or infiltration techniques.
What are the side effects of Lidocaine Hydrochloride And Epinephrine Bitartrate?▼
CNS effects include lightheadedness, nervousness, confusion, drowsiness, tremors, convulsions, respiratory depression. Cardiovascular: bradycardia, hypotension, cardiac collapse. Allergic reactions characterized by cutaneous lesions, urticaria, edema, anaphylactoid reactions, or dyspnea.
Can I take Lidocaine Hydrochloride And Epinephrine Bitartrate during pregnancy?▼
Reproduction studies in rats at 6.6 times human dose revealed no evidence of harm to fetus. No adequate well-controlled studies in pregnant women. Use with caution in pregnancy; unknown if excreted in breast milk.
What are the important warnings for Lidocaine Hydrochloride And Epinephrine Bitartrate?▼
Practitioners must be versed in emergency management. Aspiration required before injection. Contains potassium metabisulfite (sulfite). Risk of methemoglobinemia in susceptible populations. Vasoconstrictor use requires careful monitoring in cardiac patients. Contraindicated in patients with known history of hypersensitivity to local anesthetics of the amide type.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.