Valsartan And Hydrochlorothiazide
Generic Name: valsartan and hydrochlorothiazide
Brand Names:
Diovan Hct
Valsartan and hydrochlorothiazide is a combination tablet containing an angiotensin II receptor blocker and a thiazide diuretic for the treatment of hypertension.
Overview
Valsartan and hydrochlorothiazide is a combination tablet containing an angiotensin II receptor blocker and a thiazide diuretic for the treatment of hypertension.
Uses
Treatment of hypertension, to lower blood pressure in patients not adequately controlled on monotherapy or as initial therapy in those likely needing multiple drugs.
Dosage
Usual starting dose is 160/12.5 mg once daily. Can be increased after 1-2 weeks to maximum of 320/25 mg as needed. Available in five strengths: 80/12.5, 160/12.5, 160/25, 320/12.5, and 320/25 mg.
Side Effects
Most common discontinuation reasons were headache and dizziness. Nasopharyngitis occurred in 2% or greater at higher rates than placebo.
Interactions
Significant interactions with lithium, potassium-elevating agents, NSAIDs, and dual RAS blockade agents.
Warnings
Fetal toxicity: discontinue upon pregnancy detection. Drugs affecting the renin-angiotensin system cause injury and death to the developing fetus. Risk of hypotension in volume-depleted patients, impaired renal function, potassium abnormalities, and acute angle-closure glaucoma. Contraindicated with aliskiren in diabetic patients.
Pregnancy
Discontinue immediately if pregnancy detected. Causes oligohydramnios, renal dysfunction, and skeletal deformations in second and third trimesters.
Frequently Asked Questions
What is Valsartan And Hydrochlorothiazide used for?▼
Treatment of hypertension, to lower blood pressure in patients not adequately controlled on monotherapy or as initial therapy in those likely needing multiple drugs.
What are the side effects of Valsartan And Hydrochlorothiazide?▼
Most common discontinuation reasons were headache and dizziness. Nasopharyngitis occurred in 2% or greater at higher rates than placebo.
Can I take Valsartan And Hydrochlorothiazide during pregnancy?▼
Discontinue immediately if pregnancy detected. Causes oligohydramnios, renal dysfunction, and skeletal deformations in second and third trimesters.
What are the important warnings for Valsartan And Hydrochlorothiazide?▼
Fetal toxicity: discontinue upon pregnancy detection. Drugs affecting the renin-angiotensin system cause injury and death to the developing fetus. Risk of hypotension in volume-depleted patients, impaired renal function, potassium abnormalities, and acute angle-closure glaucoma. Contraindicated with aliskiren in diabetic patients.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.