Drug & Medication Database

11 DESCRIPTION TRINTELLIX is an immediate-release tablet for oral administration that contains the beta (β) polymorph of vortioxetine hydrobromide (HBr), an antidepressant. Vortioxetine HBr is known chemically as 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine, hydrobromide. The empirical formula is C 18 H 22 N 2 S, HBr with a molecular weight of 379.36 g/mol. The structural formula is: Vortioxetine HBr is a white to very slightly beige powder that is slightly soluble in water.

Brands: Trintellix

Dosage form: POWDER. Active ingredients: VORTIOXETINE HYDROBROMIDE (1 kg/kg). Category: BULK INGREDIENT.

Dosage form: POWDER. Active ingredients: VORTIOXETINE HYDROCHLORIDE (5 kg/5kg). Category: BULK INGREDIENT.

11 DESCRIPTION VOXZOGO contains vosoritide, a human C type natriuretic peptide (CNP) analog. Vosoritide is a 39 amino acid peptide. Its amino acid sequence includes the 37 C terminal amino acids of the human CNP53 sequence plus Pro Gly on the N terminus to convey resistance to neutral endopeptidase (NEP) degradation. Vosoritide is manufactured from Escherichia coli using recombinant DNA technology.

Brands: Voxzogo 0.4mg, Voxzogo 0.56mg, Voxzogo 1.2mg

11 DESCRIPTION OXBRYTA contains voxelotor, a hemoglobin S polymerization inhibitor. The chemical name of voxelotor is 2-hydroxy-6-((2-(1-isopropyl-1 H -pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde with a molecular formula of C 19 H 19 N 3 O 3 and a molecular weight of 337.4. The chemical structure of voxelotor is: Voxelotor is a white-to-yellow-to-beige compound in crystalline Form II of its free base.

Brands: Oxbryta

Dosage form: POWDER. Active ingredients: VOXELOTOR (1 kg/kg). Category: BULK INGREDIENT.

Dosage form: POWDER. Active ingredients: VOXELOTOR (1 kg/kg). Category: BULK INGREDIENT.

Dosage form: POWDER. Active ingredients: VOXILAPREVIR (20 kg/20kg). Category: BULK INGREDIENT.

11 DESCRIPTION AMVUTTRA contains vutrisiran, a chemically modified double-stranded small interfering ribonucleic acid (siRNA) that targets mutant and wild-type transthyretin (TTR) messenger RNA (mRNA) and is covalently linked to a ligand containing three N -acetylgalactosamine (GalNAc) residues to enable delivery of the siRNA to hepatocytes. The structural formula of vutrisiran sodium is presented below.

Brands: Amvuttra

Dosage form: POWDER. Active ingredients: VUTRISIRAN (1 g/g). Category: BULK INGREDIENT.

Dosage form: POWDER. Active ingredients: VANZACAFTOR CALCIUM (1 kg/kg). Category: BULK INGREDIENT.

Dosage form: POWDER. Active ingredients: ELEXACAFTOR (1 kg/kg). Category: BULK INGREDIENT.

Dosage form: POWDER. Active ingredients: DEUTIVACAFTOR (1 kg/kg). Category: BULK INGREDIENT.

Dosage form: POWDER. Active ingredients: TEZACAFTOR (1 kg/kg). Category: BULK INGREDIENT.

Dosage form: POWDER. Active ingredients: LUMACAFTOR (1 kg/kg). Category: BULK INGREDIENT.

11 DESCRIPTION VYJUVEK (beremagene geperpavec-svdt) is a suspension of an HSV-1 vector-based gene therapy, mixed with the supplied sterile excipient gel for topical application on wounds. VYJUVEK is a live, replication defective HSV-1-based vector that has been genetically modified to express the human type VII collagen (COL7) protein. The parental virus for VYJUVEK was a primary isolate, which was subsequently altered using recombinant methods to result in gene deletions and insertions.

Brands: Vyjuvek